N‐acetylcysteine attenuates ventilator‐induced diaphragm dysfunction in rats
نویسندگان
چکیده
منابع مشابه
Endurance exercise attenuates ventilator-induced diaphragm dysfunction.
Controlled mechanical ventilation (MV) is a life-saving measure for patients in respiratory failure. However, MV renders the diaphragm inactive leading to diaphragm weakness due to both atrophy and contractile dysfunction. It is now established that oxidative stress is a requirement for MV-induced diaphragmatic proteolysis, atrophy, and contractile dysfunction to occur. Given that endurance exe...
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INTRODUCTION Diaphragm weakness induced by prolonged mechanical ventilation may contribute to difficult weaning from the ventilator. Hypercapnia is an accepted side effect of low tidal volume mechanical ventilation, but the effects of hypercapnia on respiratory muscle function are largely unknown. The present study investigated the effect of hypercapnia on ventilator-induced diaphragm inflammat...
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متن کاملDysfunction of the diaphragm.
From the Department of Pulmonary, Critical Care, and Sleep Medicine, Memorial Hospital of Rhode Island, Pawtucket (F.D.M.); the Warren Alpert Medical School of Brown University, Providence, RI (F.D.M.); and the Department of Pathophysiology, University of Athens Medical School, Athens (G.E.T.). Address reprint requests to Dr. McCool at the Department of Pulmonary, Critical Care, and Sleep Medic...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.1001.10